Ger J M Pruijn Selected Research

Anti-Citrullinated Protein Antibodies

11/2023	Citrulline is not a major determinant of autoantibody reactivity to neutrophil extracellular traps.
1/2023	Mammalian Glycosylation Patterns Protect Citrullinated Chemokine MCP-1/CCL2 from Partial Degradation.
6/2017	Peptidylarginine deiminase 2 is required for tumor necrosis factor alpha-induced citrullination and arthritis, but not neutrophil extracellular trap formation.
3/2016	Extensive glycosylation of ACPA-IgG variable domains modulates binding to citrullinated antigens in rheumatoid arthritis.
1/2016	Reduced glutathione as a physiological co-activator in the activation of peptidylarginine deiminase.
1/2014	How citrullination invaded rheumatoid arthritis research.
1/2013	The rheumatoid arthritis synovial fluid citrullinome reveals novel citrullinated epitopes in apolipoprotein E, myeloid nuclear differentiation antigen, and β-actin.
1/2011	The extent of the anti-citrullinated protein antibody repertoire is associated with arthritis development in patients with seropositive arthralgia.
8/2010	Epitope spreading of the anti-citrullinated protein antibody response occurs before disease onset and is associated with the disease course of early arthritis.
1/2009	[The vicious circle that leads to rheumatoid arthritis; experimental evidence of the steps involved in this circle].

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Ger J M Pruijn Research Topics

Disease

33	Rheumatoid Arthritis 02/2024 - 08/2003
17	Autoimmune Diseases (Autoimmune Disease) 01/2023 - 01/2005
8	Myositis (Idiopathic Inflammatory Myopathies) 01/2018 - 01/2002
8	Polymyositis 01/2018 - 02/2004
8	Arthritis (Polyarthritis) 06/2017 - 01/2006
7	Systemic Lupus Erythematosus (Libman-Sacks Disease) 11/2023 - 09/2002
6	Inclusion Body Myositis 01/2018 - 03/2013
6	Dermatomyositis (Dermatopolymyositis) 01/2018 - 07/2007
5	Cartilage-hair hypoplasia 01/2022 - 11/2007
5	Inflammation (Inflammations) 01/2022 - 06/2005
4	Neoplasms (Cancer) 08/2020 - 01/2010
3	Multiple Sclerosis 03/2014 - 06/2005
2	Psoriatic Arthritis 02/2024 - 12/2016
2	Facioscapulohumeral Muscular Dystrophy 01/2024 - 01/2021
2	Necrosis 01/2020 - 12/2011
2	Relapsing-Remitting Multiple Sclerosis 06/2018 - 08/2015
2	Neuromuscular Diseases (Neuromuscular Disease) 04/2016 - 11/2015
2	Neoplasm Metastasis (Metastasis) 04/2014 - 03/2013
2	Squamous Cell Carcinoma of Head and Neck 04/2014 - 03/2013
2	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 01/2011 - 01/2010
2	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 09/2006 - 06/2005
2	Mixed Connective Tissue Disease (MCTD) 07/2005 - 01/2005
2	Systemic Scleroderma (Systemic Sclerosis) 10/2003 - 03/2003
1	Muscle Weakness 01/2024
1	Lymphoma (Lymphomas) 01/2022
1	Marginal Zone B-Cell Lymphoma (MALT Lymphoma) 01/2022
1	Rupture 12/2020
1	Infections 11/2020
1	Mitochondrial Diseases (Mitochondrial Disease) 10/2018
1	Cardiomyopathies (Cardiomyopathy) 10/2018
1	Hypertrophy 01/2017
1	Ankylosing Spondylitis 12/2016
1	Muscular Diseases (Myopathy) 12/2016
1	Chronic Disease (Chronic Diseases) 08/2015
1	Periodontal Diseases (Periodontal Disease) 05/2014
1	Periodontitis 05/2014
1	Experimental Arthritis 05/2014
1	Hypoxia (Hypoxemia) 04/2014
1	Neurodegenerative Diseases (Neurodegenerative Disease) 03/2014
1	Breast Neoplasms (Breast Cancer) 12/2013
1	Starvation 06/2013
1	Frailty 11/2012

Drug/Important Bio-Agent (IBA)

36	AutoantibodiesIBA 11/2023 - 01/2002
26	Proteins (Proteins, Gene)FDA Link 11/2023 - 03/2003
15	Peptides (Polypeptides)IBA 01/2022 - 03/2003
12	Anti-Citrullinated Protein AntibodiesIBA 11/2023 - 01/2008
11	AntibodiesIBA 01/2021 - 08/2003
9	AntigensIBA 01/2021 - 08/2003
8	RNA (Ribonucleic Acid)IBA 01/2022 - 11/2007
7	EpitopesIBA 11/2023 - 01/2005
7	AutoantigensIBA 01/2011 - 10/2003
5	Biomarkers (Surrogate Marker)IBA 01/2024 - 12/2010
5	Protein-Arginine DeiminasesIBA 06/2017 - 09/2006
4	CitrullineIBA 11/2023 - 08/2003
4	EnzymesIBA 10/2018 - 01/2006
3	5'-Nucleotidase (5' Nucleotidase)IBA 01/2018 - 03/2013
3	Amino Acids FDA Link 01/2017 - 05/2012
3	mitochondrial RNA-processing endoribonuclease (RNAse MRP)IBA 01/2017 - 03/2008
3	Fibrinogen (Factor I)FDA Link 12/2016 - 01/2010
3	Crystallins (Crystallin)IBA 04/2014 - 03/2013
2	Transfer RNA (tRNA)IBA 02/2024 - 12/2011
2	Interleukin-6 (Interleukin 6)IBA 01/2024 - 05/2014
2	MicroRNAs (MicroRNA)IBA 08/2020 - 09/2011
2	Nucleic AcidsIBA 01/2020 - 08/2015
2	Cell-Free Nucleic AcidsIBA 06/2018 - 08/2015
2	acetyl 4-aminosalicylic acidIBA 01/2018 - 06/2017
2	Immunoglobulin G (IgG)IBA 06/2017 - 03/2016
2	Messenger RNA (mRNA)IBA 04/2014 - 06/2013
2	Acetylcysteine (Siran)FDA LinkGeneric 04/2014 - 06/2013
2	Antigen-Antibody Complex (Immune Complex)IBA 01/2009 - 01/2008
2	Myelin Basic ProteinIBA 09/2006 - 06/2005
2	Glial Fibrillary Acidic ProteinIBA 09/2006 - 06/2005
2	U1 Small Nuclear RibonucleoproteinIBA 07/2005 - 01/2005
2	Small Nuclear Ribonucleoproteins (snRNP)IBA 01/2005 - 09/2002
1	Polysaccharides (Glycans)IBA 02/2022
1	DNA (Deoxyribonucleic Acid)IBA 01/2022
1	Rituximab (Mabthera)FDA Link 01/2022
1	Organosilicon CompoundsIBA 12/2020
1	SiliconesIBA 12/2020
1	Tuberculosis VaccinesIBA 11/2020
1	ProdrugsIBA 12/2018
1	Gln Transfer RNAIBA 10/2018
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 06/2017
1	HLA-DRB1 Chains (HLA DRB1)IBA 01/2017
1	Long Noncoding RNAIBA 01/2017
1	RNA Precursors (Precursor, mRNA)IBA 01/2017
1	Protein Subunits (Protein Subunit)IBA 01/2017
1	serum P-component (CIt)IBA 12/2016
1	Interleukin-17 (Interleukin 17)IBA 05/2014
1	Collagen Type II (Type II Collagen)IBA 05/2014
1	Small Heat-Shock ProteinsIBA 04/2014
1	pimonidazoleIBA 04/2014
1	Reactive Oxygen Species (Oxygen Radicals)IBA 04/2014
1	AntioxidantsIBA 06/2013
1	Methionine (L-Methionine)FDA Link 06/2013
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 03/2013
1	Differentiation AntigensIBA 01/2013
1	ApolipoproteinsIBA 01/2013

Therapy/Procedure

3	Therapeutics 12/2013 - 01/2006
1	Breast Implants (Breast Implant) 12/2020